Model of Myocarditis
نویسندگان
چکیده
Background Recently, an angiotensin-converting enzyme inhibitor was shown to have a beneficial effect on virusinduced myocardial injury. We investigated the effect of a new angiotensin II type 1 receptor antagonist, (+)-1-(cyclohexyloxycarbonyloxy)ethyl 2-ethoxy-1-{[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl}-1H-benzimidazole-7-carboxylate (TCV-116), in an animal model of viral myocarditis induced by encephalomyocarditis virus. Methods and Results Four-week-old DBA/2 mice were inoculated with the encephalomyocarditis virus. TCV-116 (in 5% gum arabic) was given 1 day before (1 or 10 mg/kg) or 2 days after virus inoculation (0.3 or 3 mg/kg). Control mice received the vehicle only. All drugs were administered orally on a daily basis, and the animals were killed on day 14. When treatment was started 1 day before inoculation, the survival of mice receiving 10 mg/kg of TCV-116 improved (17 of 20 [85%]
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